Severe ichthyosis and itching and peeling can be improved by using topical drugs such as urea cream and oral retinoids. 1. Topical drugs: commonly used urea cream, lactic acid ointment and propylene glycol solution can play a moisturizing effect, calcipotriol ointment can improve keratinization and reduce scaling, in addition to topical cholesterol cream can also significantly relieve itching and peeling. 2. Oral medication: Oral administration of vitamin A drugs such as Avitamin A can significantly relieve itching and peeling aggravated in winter. The above drugs should be used under the guidance of a doctor, and the specific treatment plan should be formulated by the doctor according to the condition.