Arms and legs with ichthyosis, mainly external drug treatment, serious patients can take oral medication for treatment. 1. Topical medication: mild, moisturizing and mildly exfoliating drugs can be used for treatment, such as the commonly used 10% to 20% urea cream, 40% to 60% propylene glycol solution, etc., which can effectively increase the degree of skin hydration, alleviate the phenomenon of dryness and desquamation; and secondly, topical preparations of retinoic acid can also be used for treatment, which can improve the keratinization and reduce the scales. 2. Oral medication: for patients with more serious symptoms, oral retinoids can be taken in winter for treatment, which can effectively improve the phenomenon of dry skin, thus alleviating the condition. Once the ichthyosis, pay attention to the hospital in a timely manner, under the guidance of the doctor to carry out reasonable treatment, the specific use of drugs need to follow the doctor’s instructions.