Ichthyosis can be relieved by topical medications such as urea creams and retinoic acid preparations, and oral medications such as isotretinoin and avitamin A. Genetics and other causes of ichthyosis cannot be eradicated. Ichthyosis is a skin disease characterized by dry, flaky skin and fish scale-like lesions, which can be white, gray or brown, and the condition often worsens in winter. The majority of ichthyosis is due to genetic factors, and a small percentage of ichthyosis is secondary to certain diseases (e.g., thyroid disease, kidney disease) or medications (hydroxyurea, niacin). Drug-induced ichthyosis can be relieved and cured after stopping the drug, while genetically-induced ichthyosis can’t be completely cured, but the symptoms can be alleviated by topical medication, such as the use of moisturizing drugs such as urea creams and lactic acid ointment, and the topical use of drugs such as Vitamin A acid preparations and Calcipotriol ointment to improve the keratinization and reduce the scales. When the disease is serious, it can also be taken orally, such as isotretinoin, avitamin A ester and other medications; secondary skin infections need to use erythromycin and other antibiotics. It is recommended that patients with ichthyosis seek medical treatment in a timely manner, standardize treatment under the guidance of a doctor, and avoid using medication privately to avoid delaying the condition. Patients should pay attention to the cleanliness of the skin in daily life to avoid secondary infection; should not use too hot water and alkaline soap to take a bath, and should not take a bath too often; try to avoid eating spicy, stimulating, cold, greasy food.