For babies with severe ichthyosis, the main treatment is basic care, topical medication such as retinoic acid, and for severe cases, oral medication may be considered. 1. Basic care: The core of the care is slight flaking and moisturizing. You can take a long shower or bath to loosen the scales, and then use a sponge ball with a rough feeling to gently scrape out the scales, not too hard, otherwise it will lead to infection. Also immediately after bathing, apply topical petroleum jelly, etc. It should be applied thickly and can be repeated several times a day. 2. Topical medication: mainly use Vitamin A cream to exfoliate, but the skin irritation is heavy, need to wait for the child to be older to use, combined with bacterial infections can be used mupirocin ointment. 3. Oral medication: oral retinoic acid tablets mainly, but the gastrointestinal reaction is heavy, need to wait until the baby is older will be safer. Severe ichthyosis babies, there may be other treatments, it is recommended to go to the hospital in time and follow the doctor’s instructions.