The difference between neonatal ichthyosis and exfoliation lies in the different causes, symptoms and treatments. 1. Causes: neonatal ichthyosis is mostly caused by genetic factors, while neonatal exfoliation is mainly caused by the lack of trace elements in the body or dry weather. 2. Symptoms: neonatal ichthyosis is mainly manifested as dry skin, flaky skin, ichthyosis-like lesions, with the color of the lesions ranging from white, gray-brown to brown, while neonatal exfoliation is mainly manifested as dry skin, peeling skin without ichthyosis-like changes. 3. Treatment: neonatal ichthyosis treatment of local topical medications, such as vitamin E milk; and neonatal desquamation can be fed warm water and rubbed moisturizing cream. If the above symptoms occur, you should consult the clinician and follow the medical advice.