There is currently no cure for ichthyosis, but most symptoms can be relieved with aggressive and effective treatment. Ichthyosis is a skin disease characterized by dry skin with ichthyosis-like scales, which is generally a lesion caused by genetic factors. It is characterized by dry skin, often accompanied by keratinization of the palms of the hands and soles of the feet, and the treatment is mainly based on topical medications to reduce dry skin and improve the appearance of the skin. Commonly used drugs include urea cream, lactic acid ointment, etc., which can play a moisturizing and exfoliation role, and topical preparation of retinoic acid can be used to improve keratinization and reduce scaling. Oral medications can be given to improve hyperkeratosis of the skin, and if secondary bacterial infection occurs, oral antibiotics such as cefixime can be used to treat the condition. Patients often have painful symptoms due to dry skin, which affects their daily lives, and current treatments only deal with dry skin and cannot completely cure ichthyosis. Therefore, patients should face up to the disease, maintain an optimistic mindset, and actively cooperate with the doctor’s treatment to promote the recovery of the disease. The application of drugs should be carried out under the guidance of professional physicians.