Acne can be caused by acne, folliculitis, eczema, etc., and should be eliminated with appropriate medication according to the cause. 1. Acne: Clogging of the ducts of the hair follicles and the propagation of Propionibacterium acnes can lead to the occurrence of acne, resulting in an inflammatory reaction of the skin on the face, which can be manifested as pimples on the cheeks. Topical retinoids such as retinoic acid ointment and tazarotene gel can be used as prescribed, as well as antibiotics such as fusidic acid cream and mupirocin ointment. If necessary, oral isotretinoin capsules and doxycycline tablets can be combined. 2. Folliculitis: due to damage to the hair follicles and secondary infection by bacteria and other pathogens, usually pimples appear on the skin, which may be manifested as a case of pimples on the cheeks. Erythromycin ointment, mupirocin ointment and other drugs can be used under the guidance of the doctor to play an antibacterial and anti-inflammatory role. 3. Eczema: Eczema is an inflammation of the superficial dermis and epidermis caused by skin irritation, which can lead to pimples, blisters and other symptoms, and may be manifested as pimples on the cheeks. Medications such as tacrolimus ointment and pimecrolimus ointment can be used under doctor’s supervision to relieve symptoms. When itching is obvious, oral antihistamines such as loratadine can be taken in combination. Pimples on the cheeks, need to go to a professional hospital for relevant examination and treatment, clear diagnosis, symptomatic treatment, the above drugs need to be used in accordance with medical advice.