In children with nephrotic syndrome, a large amount of protein is excreted, and at the same time, calcium, which is easily combined with albumin in the blood, is also excreted along with protein urine. Guo Qingyin of the Department of Pediatrics at the First Affiliated Hospital of Henan College of Traditional Chinese Medicine has a child in a stage of vigorous growth and development, and the body’s demand for calcium is relatively high. If the child does not pay attention to timely calcium supplementation or insufficient intake of calcium-containing food, the blood calcium will eventually be low, triggering hypocalcemic convulsions and hand-foot twitches. In addition, the treatment of nephrotic syndrome requires the use of adrenocorticotropic hormones, which have the effect of counteracting the absorption of vitamin D and calcium in the intestinal wall of the human body, so if the child’s condition is serious, hormones will be used for a long time, resulting in the aggravation of calcium deficiency in the child’s body. Therefore, while using comprehensive treatment for pediatric nephrotic syndrome, attention should be paid to vitamin D and calcium supplements to compensate for the calcium deficiency.