To evaluate the efficacy and side effects of vanafloxacin in the treatment of generalized anxiety disorder in children. In 76 patients with generalized anxiety disorder in children who met the diagnostic criteria of CCMD-3, 38 cases of vanlafaxine and 38 cases of alprazolam were applied to control treatment for 8 weeks, using the Hamilton Anxiety Inventory, the General Clinical Efficacy Rating Scale, and the Side Effects Scale rating scale. As a result, the efficacy of vanafloxacin and alprazolam was comparable. It was superior to alprazolam for psychogenic anxiety. Vanlafaxine had few and mild side effects. Conclusion, vanafasin is a safe and effective drug for the treatment of generalized anxiety disorder in children. Generalized anxiety disorder in children is a common type of mood disorder in children. The disorder is a chronic condition that requires long-term treatment. For many patients it may last for many years. There are three main types of medications currently available for treatment : BZ, Azaperone and antidepressants, while the BZ class of medications can be used for short-term treatment due to the potential risk of drug abuse and dependence, which limits the use of this medication for various reasons. Recent studies have reported that vanlafaxine is used to treat not only the core symptoms of generalized anxiety disorder, but also has specific effects in treating concomitant depressive symptoms and generalized anxiety. This study showed that vanlafaxine has mild side effects, and the author believes that the tolerability of the drug can be improved by slowly increasing the dose with attention to individual circumstances. Vanlafaxine is effective, safe, and well tolerated at 75-150 mmg daily for the treatment of generalized anxiety disorder in children. Further studies are needed to determine if further improvement can be achieved by extending the duration of treatment in patients who are ineffective or have poor outcomes.