Red maculopapular rash is a common skin condition that manifests as a superficial, substantial, limited elevation of the skin that is red in color, usually less than 1 cm in diameter, and may be locally aggregated or scattered throughout the body, sometimes accompanied by fever, itching, pain, and other discomforts. Red maculopapular rash refers to the red slightly elevated lesions with morphology between maculopapular rash (limited color change lesions of skin and mucous membranes without elevation and depression, with diameter less than 1 cm) and papular rash (limited, substantial superficial elevated lesions, with diameter less than 1 cm), which mainly manifests itself as papular lesions on the basis of local skin and mucous membranes with color change, and it belongs to the primary damage of dermatological diseases. The causes of red maculopapular lesions are complex and varied, and can be caused by various skin infections or physical, allergic, autoimmune and other types of skin diseases. Red maculopapular rash as a common skin symptom, need to identify the cause of the disease and then targeted treatment, please follow the doctor’s instructions. When red maculopapular rash appears, pay attention to keep the skin clean, avoid skin exposure to the sun, avoid skin contact with irritating substances or allergic substances, in order to prevent the aggravation of red maculopapular rash.