Kidney cancer is a very common type of malignant tumor in the urinary system. Generally, multiple metastases may appear in the late stage of kidney cancer, and the signs that may appear before the end of life are the functional failure of each major organ, such as lung metastasis of kidney cancer, which may lead to worsened dyspnea, decreased oxygen saturation, and heavier hemoptysis, cough and sputum, and this condition may also directly lead to respiratory failure, resulting in the patient’s death. In addition, pelvic metastasis is more frequently seen in kidney cancer, which may lead to huge pelvic masses, compression of intestine or cause intestinal fistula, etc. These are also signs of terminal illness. Kidney cancer may also develop bone metastasis, which may cause bone pain and pathological fracture in severe cases. For advanced kidney cancer, you can try to apply targeted drugs, such as sorafenib, pegaptanib, sunitinib treatment, which can also alleviate the disease progression and prolong the survival.