Warts infection in pregnant women can be a particularly difficult problem. On the one hand, local hormone levels change during pregnancy, and warts can grow more rapidly once they are infected. On the other hand, clinical trials of drugs are not permitted in pregnant women, so there are only case reports and no large-scale clinical trials to confirm whether a particular treatment is harmful to pregnant women. Therefore, topical medications may enter the body of pregnant women through the mucous membranes in the treatment of warts, which is not yet supported by evidence-based medicine and is not advocated at this time. The principle of treating warts in pregnant women is for the patient to pay attention to local cleaning. If the warts are growing rapidly and the patient is desperate for treatment, cryotherapy or laser treatment can be done. However, freezing and laser treatment can cause pain to the patient and may even cause an early delivery, which can be troublesome to deal with once it occurs. Generally, after full communication with the patient, I advocate the application of cryotherapy. Because relatively speaking, the possibility of infection after laser treatment is greater than that of cryotherapy, and in case of infection, the treatment will be more complicated for pregnant women.