Acne on both sides of the jaw may be related to androgen levels, proliferation of Propionibacterium acnes, and abnormal keratinization of follicular sebaceous gland ducts. 1. Androgen level: High androgen level and abnormal androgen receptor can cause excessive sebum secretion, resulting in acne on both sides of the jaw. 2. Proliferation of Propionibacterium acnes: Once the skin on both sides of the jaw becomes dysbiotic, causing a proliferation of Propionibacterium acnes, an inflammatory reaction can be caused, resulting in the appearance of acne. 3. Abnormal keratinization of follicular sebaceous gland ducts: If the follicle mouth is over-keratinized, resulting in duct obstruction, it can prevent the normal discharge of shed epithelial cells and sebum, which can lead to the formation of pimples. It is recommended that people with acne on both sides of the jaw go to the hospital in time to clarify the cause of the disease, and standardize the treatment under the guidance of the doctor.