The difference between epididymitis and prostatitis is that the epididymis is located in the back of the testicles within the scrotum, and when inflammation occurs, it can appear with local swelling and pain. The prostate gland is located in the posterior urethra and is connected to the bladder at the rear and cannot be touched or seen on the body surface. 2. The symptoms are different. It is usually not accompanied by abnormalities in urination. The actual fact is that you can find a lot of people who are not able to get a good deal on this.