1, rest: general patients can be appropriate activities, excessive restriction of the body can promote the patient secondary infection and osteoporosis, but never strenuous activities, should avoid excessive load, to prevent falls, bruises, depending on the specific circumstances of the use of lumbar girth, splints, but to prevent the resulting poor blood circulation. If the patient is prone to comorbidities due to prolonged illness and reduced immune function, he should rest in bed and reduce activities. When there is bone destruction, absolute bed rest should be taken to prevent causing pathological fracture. 2. To prevent pathological fracture: patients should sleep on a hard bed and avoid using elastic bed. Maintain a comfortable lying position to avoid injuries, especially injuries from falling out of bed. 3.Diet: Eat a high-calorie, high-protein, vitamin-rich and easy-to-digest diet. Should eat more food to inhibit the excessive proliferation of bone marrow, such as kelp, nori, wakame, sea clams, almonds; abstain from smoking and alcohol, avoid eating fat, sweet and thick taste and cold, spicy products; patients with renal insufficiency, should eat low sodium, low protein or wheat starch diet, to reduce the burden on the kidneys. If you have hyperuricemia and hypercalcemia, you should drink more water and keep the daily urine volume above 2000ml to prevent or reduce hypercalcemia and hyperuricemia. 4.For elderly bedridden patients with limited limb movement, they should be assisted to turn over regularly and gently to avoid fracture. The skin under pressure should be given warm towels for massage or physical therapy, and the bed should be kept dry and flat to prevent bedsores. 5, oral cleaning: patients with renal impairment, due to excessive accumulation of metabolites, part of the waste into the respiratory tract discharge and produce bad breath, affecting appetite, should do a good job of oral care, and give 0.05% chlorhexidine solution and 4% sodium bicarbonate solution alternate gargle to prevent bacterial and fungal infections. 6. Pain: As the disease progresses, bone pain symptoms are difficult to relieve, and the degree of bone pain varies, mainly occurring in bones rich in red bone marrow, such as ribs and sternum. Nerve roots may appear as neuralgia due to pressure. One should communicate more with others or do more things of interest to distract oneself. Those with severe pain should use sedative painkillers in appropriate amounts as prescribed by the doctor. Local radiotherapy may also be administered to reduce symptoms. Patients with neuropathic pain can take corresponding local closure or physiotherapy. 7. Anemia: pay attention to monitoring the changes of blood picture and take appropriate treatment measures according to the degree of anemia. 8. Prevention of infection: respiratory tract infection and pneumonia are common in this disease, followed by urinary tract infection, so the room should be kept clean air, appropriate temperature and humidity, avoid cold and prevent cross-infection, frequent change of position, timely sputum discharge; encourage hydration and diuresis. 9, chemotherapy: patients should drink more water during chemotherapy, daily fluid intake of not less than 3000ml, and alkalinize urine, accurately record the amount of fluid to maintain water-electrolyte balance. 10. Mood: With the emergence of various targeted therapeutic drugs in recent years, the survival period of multiple myeloma patients is getting longer. Maintaining an optimistic and stable state of mind is more conducive to the treatment of the disease.