The principle of targeted therapy for lung cancer is to take the drug orally until the tumor progresses, and when the drug is resistant, the drug will end and be replaced by another drug. If a patient is taking this drug and the toxic side effects are so great that the patient cannot tolerate it, or the toxic side effects have become severe or more, it is recommended that this drug should also be discontinued. Generally, as long as the drug is effective or tolerated and no major toxic side effects occur, it should also be used for a long time. For patients with adjuvant drugs after surgery, especially anti-angiogenic drugs, there is also no clear course of treatment, and it is recommended to generally maintain the use until the disease progresses, or until the toxic side effects are intolerable.