Long-term drinkers mainly protect the liver and stomach through general treatment and medication. Long-term drinkers should eat properly before drinking, avoid drinking on an empty stomach, if drinking on an empty stomach, it will lead to the enhancement of the irritation of alcohol on the gastric mucosa, which can easily cause gastric diseases or aggravate gastric diseases, and avoid frequent alcohol abuse, which can easily increase the burden on the liver and cause liver diseases, such as alcoholic hepatitis. If the drinking of alcohol leads to stomach discomfort, for example, frequent stomach acid may be caused by gastric mucosa damage, need to take appropriate acid inhibiting drugs and drugs to protect the gastric mucosa, such as omeprazole, rabeprazole, and bismuth potassium citrate, bismuth pectin, and so on. If it leads to liver function damage, it is necessary to take hepatoprotective drugs, such as compound glycyrrhizin and reduced glutathione. In addition, try to avoid long-term alcohol consumption, which can easily lead to stomach and liver damage.