The brain, as an important part of the human body, has an important driving role in daily life in terms of mood change, decision making and taking action. While people cannot help but praise it for its powerful functions, they are unaware that there is a natural helmet on the surface of the brain that is always protecting our brain from external injuries, which is our cranium. In spite of a thousand precautions, still can not avoid the advent of some accidents, such as car accidents, collision, fall, etc. will make our brain injury, many patients need to perform de-bone flap decompression surgery for treatment, leaving behind the skull defects, serious head collapse. Without the protection of the skull, it is not only easy to cause instability of intracranial pressure or intracranial abnormality, but also easier for patients to develop psychological disorders, low self-esteem, depression, irritability and so on. Therefore, timely cranial bone repair is needed. Although the neurosurgery department of some domestic hospitals widely use titanium mesh cranial bone repair, cranial bone repair for patients, but the postoperative feedback is not good. So, what are the side effects of titanium mesh skull repair? It was found that titanium mesh is essentially a metal property, take the covering repair method, and the material performance is not good, tissue compatibility is not ideal, thermal insulation is not good, hardness is not high, shaping effect is not very good, there may also be many postoperative complications, common rejection of infection, titanium mesh exposed, CT MRI is affected and so on. Therefore, patients should further seek for more advanced and mature technology when preparing for cranial repair.