OBJECTIVE: To investigate the clinical value of hybridization treatment for lower limb arterial ischemic diseases. Methods: We collected data from 70 patients (86 limbs) with lower extremity arterial ischemia from March 2008 to March 2011, and applied a combination of balloon embolization, intraoperative angiography, balloon dilation and/or stenting, artificial vascular bypass, and other hybrid surgical methods according to the different conditions of the affected limbs. local debridement, continuous negative pressure drainage (vacuum sealing draina, VSD), special dressing changes, and other treatment measures. Results: Forty-five cases of thrombus were found and removed angioscopically, among which 41 cases of combined iliofemoral artery with varying degrees of stenosis required simultaneous endoluminal treatment, while 25 cases were treated directly with endoluminal treatment or bypass surgery without finding thrombus or without angioscopic access. The postoperative pain relief rate was 97.5%, the 1-month ulcer healing rate was 87.8%, the 1-year patency rate was 86%, and there were 2 perioperative deaths. In all cases, the symptoms were relieved one week after surgery. Conclusion: Lower extremity arterial ischemic diseases are complex and diverse, and individualized assessment is required. The flexible and diverse treatment by surgical and endoluminal hybrid one-stop approach is satisfactory and worthy of clinical promotion.