1, the significance of biopsy: some physicians rush to perform partial resection or scraping of tumor without preoperative pathological biopsy, only to find out it is malignant tumor after surgery – as a result, they should do major surgery but did minor surgery, resulting in the spread of tumor cells and difficult to clean up. Likewise, some physicians perform a very large and risky surgery for what they believe to be a malignant spinal tumor, only to have the postoperative pathology confirm that no surgery is needed, or only minor surgery is required. The above situation is not uncommon in clinical practice – misdiagnosis and misdiagnosis caused solely by clinical experience will seriously affect the prognosis and survival quality of patients and bring new hazards. 2. Inpatient or outpatient examination: If the lesion is relatively large and the biopsy is safer, the puncture biopsy is usually booked in the outpatient clinic. If the patient is young, uncooperative, or the lesion is relatively risky to biopsy, then inpatient biopsy is performed. 3. Risk: There are blood vessels, spinal cord and nerve roots around the lesion, so biopsy has certain risks. However, Ning Medical General Hospital has been conducting CT-guided biopsies for 6 years and has experience in hundreds of biopsies. The risk is not too big, and there is a whole set of plans to deal with and cope with the risk. 4. Before biopsy, you need to prepare: outpatient laboratory checklist (chest X-ray, ECG, routine blood, biochemistry, immuno-eight, coagulation), and MRI + enhancement (to understand tumor boundary). For patients who need to be hospitalized for biopsy, a hospitalization order will be issued. For patients who do not need biopsy or cannot be biopsied, “incisional biopsy” or “observation” will be arranged according to the preliminary diagnosis of the radiology department. If the lesion is soft tissue, it is usually biopsied by ultrasound. If the patient cannot cooperate (for example, children), anesthesia is required (general anesthesia is possible). 5, biopsy pathology, etc.: generally 7-14 days to report, need to be discharged from the hospital in the outpatient clinic, etc. If surgery is needed, the patient can be hospitalized again in 2-3 days. If surgery is not required, treatment and therapy recommendations will be informed.