Itchy hands in the middle of the night, most are symptoms of mosquito bites, scabies, eczema or contact dermatitis. You need to go to the hospital dermatology department in time, and use medication under the guidance of the doctor. 1. Mosquito bites are common in summer and fall, especially in the southern region, heavy body odor or young children are relatively easy to be insect bites. 2. Scabies is caused by scabies infection of the skin, because scabies like night activities, so there will be an itchy hand in the middle of the night. 3. Eczema is caused by internal and external stimulation of a variety of factors, in the middle of the night, due to the surrounding environment is quiet, people’s attention is focused, the hands are easily stimulated by external factors and itchy. 4. Contact dermatitis is the skin of the hands in contact with certain allergens or irritants caused by local allergic reactions, many people are watches, rings and other items allergic. There may be other reasons for itchy hands in the middle of the night. It is recommended to go to the hospital if necessary.