Renal cortical necrosis is a rare form of arterial infarction characterized by necrosis of cortical tissue followed by calcification. It is located precisely in the subperitoneal area, with no involvement in the proximal medullary area or in the medulla. Renal cortical necrosis can occur at any age. In women, complications of pregnancy (e.g., placental abruption, placenta praevia, uterine bleeding, puerperal sepsis, amniotic fluid embolism, intrauterine death, preeclampsia) account for more than 50% of cases, while bacterial sepsis accounts for 30%. Other causes include hemolytic-uremic syndrome, super-acute rejection of transplanted kidneys, burns, pancreatitis, snake bites and poisoning (e.g. phosphorus, arsenic). About 10% of cases occur in infancy and childhood. In neonates, more than 50% of cases are caused by placental abruption and the next common cause is bacterial sepsis. In children, infection, extracellular volume loss, shock and hemolytic-uremic syndrome are common causes. Suspected mechanisms include vasospasm, activation of coagulation mechanisms, endotoxin, immunologic injury and direct endothelial cell damage. The damage is extremely similar to the general Shwartzman phenomenon in animal studies. Renal cortical necrosis is the result of obstruction of small arteries in the renal cortex due to various diseases. Other causes include rejection of the transplanted kidney, burns, inflammation of the pancreas (pancreatitis), injuries, snake bites, and poisoning. 1. Low-protein diet: In a low-protein diet, high-quality protein should be the mainstay, such as milk, eggs, fish and lean meat, and the caloric energy in the diet must be sufficient. At least 35 kcal per kilogram of body weight. How to increase the amount of high quality protein in the diet and reduce the amount of vegetable protein, nowadays, wheat starch is often used clinically as the main source of caloric energy. Corn starch and potato starch can also be used instead of rice and flour. Because of the low vegetable protein in starch, it contains 0.4 to 0.6 grams of vegetable protein per 100 grams, while flour contains 6 to 10 grams of vegetable protein per 100 grams. Clinically, plant protein will be saved to be supplemented with animal protein such as eggs, milk, lean meat, etc., so as to meet the physiological needs of the body. This can meet the caloric energy needs, on the other hand, can also correct the abnormal amino acid metabolism in the body. 2, essential amino acid diet therapy: chronic renal insufficiency patients have a low proportion of plasma essential amino acids and high non-essential amino acids. Some scholars found that the above diet is well utilized and easy to obtain nitrogen balance. Some scholars believe that oral essential amino acids can promote liver protein synthesis, and intravenous injection promotes muscle synthesis. With essential amino acids, protein intake is lower than that of high biomass low protein diet, which can meet the need of essential amino acids in the body, easily obtain nitrogen balance, and reduce nitrogen metabolites; at the same time, phosphorus intake can be reduced, so it can reduce the damage of calcium deposition to kidney units. In addition, the choice of protein is not limited to high biomass-priced protein, which is conducive to adjusting the patient’s taste and making it more acceptable to the patient.