Nowadays, “high blood pressure, high blood cholesterol and high blood sugar” are the three major diseases that plague modern human beings. Once hypertension is formed, the need for long-term or even lifelong medication has been widely recognized. Some patients think that if their blood lipids are normal, they do not need to continue to take medication, while others are reluctant to take medication because they are worried about the side effects of lipid-lowering medication. In response to this doubt, we should analyze the specific problems, according to age, cardiovascular disease, family history of cardiovascular disease, blood lipid level, cardiovascular and liver and kidney function status and other specific circumstances, and make a comprehensive analysis, and under the premise of respecting objective evidence, doctor’s experience and patient’s will, combine with clinical guidelines, choose the appropriate drugs and take them for the right time to get a more ideal result. This is our common wish. First of all, we should clarify the relationship between cholesterol and atherosclerosis. As the old saying goes, “If you know yourself and your enemy, you will never lose a hundred battles. Centennial cholesterol theory confirms that elevated blood cholesterol and low-density lipoprotein are the main causes of atherosclerosis, that is, “without cholesterol, there is no atherosclerosis.” In particular, LDL is easily retained in the arterial intima and even infiltrates under the intima, when the body’s scavenger macrophages will engulf LDL and turn into bloated and hypertrophic foam cells, resulting in reduced activity, and the cells will accumulate together and fuse and rupture, releasing harmful lipid substances to destroy the vascular endothelium, and these lipid wastes will take root and gradually accumulate. Day after day, year after year, the formation of lipid plaque lesions, resulting in narrowing of the blood vessel cavity, resulting in blood supply disorders, making organs and tissues ischemia and hypoxia, which is the culprit of coronary heart disease, myocardial infarction, cerebral infarction, and atherosclerosis of the extremities. Under normal circumstances, the various cells in our body and the organ systems are in dynamic balance through highly complex interactions, so that the lipid metabolism is in a state of dynamic equilibrium and the lipid waste produced is removed in a timely manner. Just like a huge chemical factory, from the raw materials into the factory to the products out of the factory, each link, each process must meet the design requirements. The fatty food we consume, after completing their respective functions, the remaining part becomes lipid waste, which then requires macrophages, vascular endothelial cells, and various biochemical enzymes to process this waste, as well as transporters such as HDL and Apolipoprotein A to transport LDL and very low density lipoproteins to the liver for processing. As we age, the function of our own organs and the efficiency of their work will gradually decline. Sometimes our factories also have the phenomenon of aging equipment and negligence, and the production capacity is insufficient, specifically in the human body, cholesterol, LDL and triglycerides are elevated, while HDL and ApoA are lowered, and the imbalance of these substances causes disorders of human lipid metabolism. At this time, we need to rely on lipid-regulating drugs to help regulate lipid metabolism, so that what should be raised and what should be lowered can be balanced. Why should we take lipid-lowering drugs for a long time? To date, studies including animal experiments, cytology experiments, epidemiological surveys and hypercholesterolemia-related genes have supported elevated LDL and cholesterol as the main cause of coronary heart disease. The history of the use of the most commonly used statin lipid-lowering drugs begins in the 1980s with the use of statins for the treatment of hyperlipidemia, and the landmark clinical study “The 4S Study”, also known as the “Scandinavian Simvastatin Survival Trial”, published in 1994, first confirmed the use of statins in the treatment of hyperlipidemia. The 4S study, also known as the Scandinavian Simvastatin Survival Trial, was the first to demonstrate that the use of statins could lower cholesterol levels and reduce the incidence of adverse cardiovascular events. This was followed by the West of Scotland Coronary Heart Disease Prevention Study (WOSCOPS), the Cholesterol and Coronary Recurrent Events Study (CARE), the Long-Term Intervention with Pravastatin in Ischemic Heart Disease (LIPLD), and the Air Force Texas Coronary Atherosclerosis Prevention Study (AFCAPS/Tex CAPS). These landmark large-scale clinical trials confirmed that aggressive lowering of cholesterol and LDL levels significantly reduces coronary heart disease events and can reduce coronary heart disease and coronary heart disease-related mortality. In these 20+ years, there have been numerous studies applying statin lipid-lowering drugs to treat hyperlipidemia, coronary atherosclerosis, diabetes, such as the TNT, PROVE-IT, IDEAL and AtoZ studies, and the newly published IMPROVE-IT study, which involved 18,144 patients with acute coronary syndromes over a 9-year period, this study tells Even if LDL returns to normal, the drug should be continued with confidence and should not be reduced or discontinued in the absence of liver and muscle side effects. The above large-scale clinical trials have demonstrated that long-term use of statin lipid-lowering drugs can reduce the chance of myocardial infarction and cerebral infarction in patients with atherosclerosis. The clinical implications revealed by these evidence-based medical evidences have encouraged the medical community that hyperlipidemia and atherosclerotic diseases are no longer incurable, and long-term survival of patients with myocardial infarction and cerebral infarction is possible, with greater benefits from long-term drug use. Side effects of long-term application In the past, we did not recognize that high-dose lipid-lowering drugs could have so many side effects. With the establishment of an adverse drug reaction monitoring system, we found that high-dose use of lipid-lowering drugs could cause many little-known side effects. That’s why the U.S. Food and Drug Administration has warned all medical professionals that a doctor’s responsibility lies not only in prescribing medications, but in his or her duty to instruct, and that it is his or her responsibility to tell the patient what function the drug will have and what side effects it will cause once it enters the body. The most commonly used statins are lipid-lowering drugs, and there is a quantitative-effect relationship between their effects and side effects. A regular or moderate dose of statin can significantly lower LDL with a significant reduction in side effects, while a high dose of statin can lower LDL with only a 6% increase in efficacy and a significant increase in adverse effects. Therefore, the side effects of statins are dose-related, and no serious side effects have been found in long-term small doses through nearly 20 years of clinical application. However, when applied in large doses, it is like a double-edged sword, which can greatly harm oneself if one is not careful while rapidly killing the enemy. This is the characteristic of duality in everything, each has its own advantages and disadvantages from different perspectives, but lowering LDL is the hard truth and the main contradiction. It is safe to take it in small or regular doses for a long time. To sum up, patients and friends suffering from coronary heart disease, acute coronary syndrome, diabetes mellitus and with several cardiovascular high-risk factors, long-term use of small or conventional doses of statin lipid-lowering drugs can significantly reduce the occurrence of cardiovascular and cerebrovascular accidents, even if LDL is reduced to normal, they should continue to take the drugs, and practice proves that small doses are safe and reliable, and continuously keeping normal blood lipids and controlling LD Lipoprotein control can be beneficial in the long term.