Neonatal ABO hemolysis refers to neonatal hemolysis caused by the ABO blood type incompatibility between the baby’s mom and the newborn. This condition is mostly seen when the baby’s mom’s blood type is O and the baby’s blood type is A or B. If the baby’s father is not type O, then the baby may have ABO hemolysis. Generally this situation can occur in the baby mother’s 1st child, O type baby mother before pregnancy, stimulated by nature A or B blood type antigen analogues, after pregnancy baby red blood cells on the blood type antigen will enter the mother through the placenta, the mother will produce anti-A or anti-B antibodies, these antibodies against the fetal red blood cells will enter the fetus through the placenta, combined with the fetal red blood cells on the blood type antigen, the fetus The red blood cells are destroyed, which means that hemolysis occurs, resulting in jaundice and anemia early after birth. The condition of ABO hemolytic disease varies in severity and can generally be controlled with appropriate treatment methods, such as medication and light therapy, and only a relatively small number of babies require blood exchange treatment. With the continuous improvement of modern medical technology, even if a fetus is diagnosed with neonatal hemolytic disease after birth, it can be cured with active treatment and proper methods.