Recurrence of nephrotic syndrome in children is very common, generally about 70% will recur, of which about 30% will recur frequently. However, in clinical work, when a child has a relapse, the same urine protein is above 3+, some children have a relapse after a cold and cough, that is, a relapse with an infection trigger, while others have a relapse without any signs. So are these two types of relapses treated the same? My experience is different. Simply put, for the relapse induced by infection, we usually check the blood routine, CRP and Mycoplasma pneumoniae first, and choose different anti-infection treatment according to the pathogen. There are exceptions. For relapses without any signs, there are actually triggers, but they are not detected by parents and doctors, for this kind of relapse, it is usually necessary to check the routine blood, CRP and Mycoplasma pneumoniae, but often no signs of infection can be found, then this kind of relapse may be caused by the insufficient dose of hormone, and it is necessary to increase the dose of hormone, usually to the last dose, because this kind of relapse often occurs soon after the last dose reduction. Some doctors and parents of children, once they see a large amount of urine protein, rush to increase the hormone by many tablets at once, which is actually unnecessary.