Typical membranous nephropathy does not heal on its own, but can resolve clinically on its own or with aggressive treatment, but the disease can recur. Atypical membranous nephropathy is a pathological type of nephrotic syndrome or chronic nephritis. Atypical membranous nephropathy requires active blood pressure control to reduce proteinuria, and antihypertensive drugs are chosen from angiotensin-converting enzyme inhibitors and angiotensin receptor blockers to reduce proteinuria and protect renal function. If proteinuria >1g/24h, blood pressure needs to be controlled below 125/75mmHg; if proteinuria <1g/24h, blood pressure needs to be controlled below 130/80mmHg. If the clinical presentation of massive proteinuria is consistent with the diagnosis of nephrotic syndrome, hormone combined with immunosuppressive therapy is recommended. If proteinuria continues to turn negative and renal function is stable, the prognosis is good; if proteinuria continues to be unremitting and renal function declines, the prognosis is not good. Chronic renal failure occurs when renal function declines, and chronic renal failure then progresses chronically and progressively until the end stage of renal failure, i.e., the uremic phase. Once clinical symptoms of uremia appear, such as digestive system symptoms, like nausea, vomiting or even gastrointestinal bleeding, chest tightness, shortness of breath, and other manifestations of heart failure, it is time for renal replacement therapy, such as hemodialysis or peritoneal dialysis treatment.