Cerebral infarction is usually acute in onset and rapid in change. Chinese and Western medicine circles have been constantly searching for effective treatment methods, and significant progress has been made in recent years. The research and application of the method of promoting water circulation in the acute stage of cerebral infarction are summarized as follows: 1. The thesis of the method of promoting water circulation is based on Shen Xiaoming, Department of Cerebral Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine. The brain is the most important organ of the human body, and it is the place where the essence of blood and qi is converged, and the “twelve meridians and three hundred and sixty-five collaterals are injected in the face and go through the empty orifices” ( Ling Shu. Evil viscera disease form chapter”). Qi and blood to the head orifices of the warmth, filling irrigation, moistening effect are through the crisscrossing veins infiltration and realization. The brain is the capital of the spirit, and the normal function of the brain is dependent on the smooth flow of the brain and the adequate supply of qi and blood. Chinese medicine theory believes that blood and water (Jin) are one of the basic substances that make up the human body, and there have always been the same source of Jin and blood, blood and water related to say. For example, “Ling Shu. Evil guest chapter” said: “the camp gas, its fluid, injection in the veins, into blood”. Qing. Tang Rongchuan in the “blood evidence” in the cloud: “blood get gas change steam, but also the water”, “water for the blood of the initiative, gas line is water line, water line is blood line” [1]. Explained the fluid and blood Physiological have the same source of mutual aid, mutual root and coexistence of the close relationship. Physiological connection, will inevitably lead to pathological correlation. The pathology of blood has blood stasis, and the pathology of water has phlegm-drinking and water turbidity. Blood stasis and phlegm, water turbidity are the products of pathological changes in the course of human disease, and can become new pathogenic factors under certain conditions, stasis can lead to water, water can stagnate blood. Blood stasis, fluid transmission difficulties, waterways are not open to cause water stoppage, that is, “blood is not good for water”; at the same time, water and dampness stopping congestion of qi, blood flow is not smooth, causing or aggravating blood stasis. Lung, spleen, kidney dysfunction or San Jiao qi unfavorable, or the meridians run unfavorable will lead to fluid can not be normal distribution, fluid gathered into phlegm. Phlegm is the initial stage of stasis, and stasis is the further development of phlegm. Brain orifices are valued for their clearness and fluency, once acute cerebral infarction, the cerebral collaterals are stagnant, the blood is unfavorable to water, the water and fluid do not work, and condense into phlegm, and seepage into drink, stasis of blood, phlegm and drink, and water and turbidity congestion of the collaterals and channels, and gradually become the pathology of stasis of water and water interconnecting the cranium [2]. 2. The etiology and pathogenesis of the acute phase of cerebral infarction The patients in the acute phase of cerebral infarction mostly have consciousness disorder and cerebral edema, and the intracranial pressure is increased. It is similar to the middle viscera in stroke disease in Chinese medicine. Chinese medicine believes that the occurrence of stroke is mostly based on the weakness of qi and blood in the body, and yin and yang in the internal organs. In a variety of stimulating factors style, wind, fire, phlegm, false, gas, blood and other factors interlaced for the patient, resulting in viscera yin and yang imbalance, qi and blood in the brain and caused by the chaos in the middle. And phlegm and blood stasis are the main pathogenesis of stroke disease. And in the evolution of its pathogenesis, it produces internal toxicity, craniocerebral water stasis, toxic damage to the cerebral collaterals of the pathogenesis of damage [3]. Leng [4] observed 98 cases of acute-phase stroke patients and concluded that the acute phase is the presenting deficiency, with phlegm, wind, and fire-heat syndromes being the majority of the real symptoms, especially phlegm, and almost all the patients had the manifestations of phlegm such as phlegm cackling, phlegm obstruction in the throat, and white and greasy tongue coating (accounting for 95.8% of the cases). Wang Yunxiang [5] considered the standardized solid as blood stasis in the veins. According to Zhang Deshan [6], the specimen of ischemic stroke is phlegm and blood stasis, and the pathogenesis is internal stasis of blood and paralysis of the cerebral channels. Wang [7] reported that phlegm and stasis accounted for 85% of the cases, and phlegm and stasis were mutually causative, with phlegm caused by stasis and stasis caused by phlegm. According to Wang Jingyu [8], wind and fire are incited, phlegm and stasis are congested, and viscera and qi are impassable as the symptoms, and wind and fire, phlegm and stasis are more prominent. Modern medical research believes that cerebral edema and blood circulation disorders are the two main pathological links in the acute stage. Cerebral infarction due to cerebral tissue ischemia and hypoxia, sodium-potassium pump failure, intracellular sodium and water retention, calcium ion in-flow increased, resulting in cytotoxic cerebral edema; subsequently, due to the destruction of the blood-brain barrier, the vascular permeability increases, intravascular water and blood components seepage caused by vasogenic cerebral edema. Cerebral edema often worsens ischemia and hypoxia, and the reduction of local cerebral blood flow can contribute to further aggravation of cerebral edema [9]. This confirms the theory of blood-water correlation in TCM and the theory of pathomechanism of collateral stasis from the perspective of micro-dialectical evidence, and provides supporting evidence for the theory of pathomechanism of phlegm-stasis and water obstruction of cerebral collaterals in the acute stage of cerebral infarction. 3.Experimental studies on the treatment of acute cerebral infarction by water-liquidizing and collaterals-passing method There are not many people who explicitly proposed water-liquidizing and collaterals-passing method for the treatment of acute cerebral infarction, and there are some related therapies from the report. 3.1 Resolving blood stasis, inducing diuresis, waking up the brain and opening up the mind: Xie Jianguo [10] and others used the pure traditional Chinese medicine preparation Zhongfeng Kangbifu to carry out a controlled study on the pharmacodynamic mechanism of the effect of the internal environmental disorders in the brain tissue of rabbits with cerebral infarction and found that this therapy can effectively restore and improve the reduction and correction of the disorders of the T3 and the cortisol exemptions induced by cerebral infarction, and that the degree of its therapeutic effect was not significantly different from that of the healthy group; and it can obviously reduce the T3 and cortisol exemptions induced by cerebral infarction. The results showed that this therapy can effectively restore and improve the reduction of T3, cortisol release value and correct the disorder caused by cerebral infarction, and the degree of therapeutic recovery is not significantly different from that of the healthy group. Thus, it suggests that the method of resolving blood stasis and inducing diuresis and waking up the brain and opening up the mind is an effective method for early recovery in the treatment of cerebrovascular disease. Guo Zhouke [11] found that Fuxuan Wake-Up Brain Liquid has the exact effect of reducing cerebral edema in experimental animals, and its effect is not as rapid as that of mannitol, but it is more stable and long-lasting than that of mannitol. 3.2 Activating blood and promoting water circulation: Shao Nianfang [12] aimed at the characteristics of the pathogenesis of reversal of qi in the acute stage of stroke disease, stasis of blood in the brain complex and stasis of cranial and cerebral water in the cranial brain. According to the theory of blood and water related to the motherland medicine, the drink of activating blood and promoting water circulation (15g of Zelan, 6g of leech, 6g of rhubarb, 3g of Panax notoginseng powder, 30g of Pueraria lobata, 30g of Zedoary, 30g of Atractylodes macrocephala, 24g of Rhizoma Atractylodes macrocephala, 12g of Calamus calamus) was formulated. Animal experiments showed that this formula can reduce the permeability of the capillaries of brain of ischemic rats, inhibit the reaction of lipid peroxide in the rabbit with cerebral ischemia – reperfusion, suppress Platelet aggregation, the mouse brain ischemia-hypoxia state of the respiratory center has a certain excitatory effect, and can improve the hypoxia resistance of brain tissue. Yan Huijun [13] believed that qi deficiency and blood stasis is the pathological basis of cerebral edema in the acute phase of ischemic stroke, and stasis and water interconnection and blockage of collaterals and congestion are the key pathomechanisms of the disease, and the effects of the pairing of Astragalus, Panax notoginseng, leeches, and motherwort on the water content of the brain, capillary permeability, blood viscosity, platelet aggregation, MDA content, SOD activity, and the effects on the histology of the brain of acute cerebral ischemic rats were confirmed to be a key factor in the treatment of acute ischemic brain edema in the acute phase of ischemic stroke. the main treatment for cerebral edema in the acute stage of stroke. 3.3 Method of dispelling phlegm and activating blood: Blood stasis and phlegm are important pathogenic factors in the pathogenesis of stroke, and at the same time are its pathological products, which are often combined with each other, and phlegm and blood stasis are blocked in the cerebral orifices and develop. Enhanced C-fos gene expression in brain tissue after cerebral ischemia and reperfusion has become a consensus, and it is believed to be related to the occurrence of cerebral edema and amino acid toxicity, so inhibiting C-fos gene expression will help to improve the post-ischemic brain operation. Zhang Bosheng[14][15] experimentally confirmed that the traditional Chinese medicine compound formula (Gui Zhi Fu Ling Wan plus Chuan Xiong Xiong and Ze Xie) with phlegm and blood stasis could effectively inhibit the C-fos gene expression in brain tissues after cerebral ischemia and reperfusion, and it could significantly reduce the content of GLU.ASP, GLY, and CABA in the rat brain tissues and serum, which indicated that this formula had an obvious anti-amino acid toxicity of cerebral ischemia, and it would help to reduce the ischemic brain edema and the It helps to reduce ischemic brain edema and repair brain cell damage. 4.Clinical application According to the evolution of pathophysiology in modern medicine, cerebral infarction is clinically divided into ultra-early stage, within 6 hours of onset; early stage, within 6-72 hours of onset; post-acute stage, within 72 hours-1 week of onset; and recovery stage, one week after onset [16]. Early thrombolysis is an important means for Western medicine to treat cerebrovascular disease, reduce the morbidity and mortality rate, disability rate, and improve the therapeutic effect, but due to the limitation of the conditions of thrombolysis and the side effects such as causing hemorrhage, in fact, only about 2% of the patients with cerebral infarction are suitable for thrombolysis [17]. The treatment of cerebral infarction with Chinese medicine is a specialty of China, and its application is quite common and recommended by many well-known scholars [18]. 4.1 Research on the rules and treatments The earliest Chinese medicine practitioner to discuss the treatment of stroke paralysis was Hua Tuo in the Han Dynasty, who said in Zhongzangjing: “When a person is ill with stroke paralysis, his pulse is counted, and his face is dry and black and sallow, his hands and feet are inactive, and his speech is awkward, what can be done to treat it? In the upper part of the body, it is vomited; in the middle part, it is diarrhea; in the lower part, it is tonic; in the outer part, it is sent out; in the inner part, it is warmed, pressed, and ironed.” Later generations of medical practitioners have their own play, the treatment method is very many, diuresis is one of them. Lishui Tongluo belongs to the category of “elimination method” of “eight methods” of Chinese medicine treatment, that is, through the method of dissipation, so that the water, phlegm, stasis accumulated in the cranial brain of the real evil gradually dissipate to be discharged from the body, so as to achieve the smooth brain, blood flow, God has a master. 4.1.1 The method of activating blood and promoting water:Luo Feng[19] believes that this method has better curative effect on patients with acute ischemic stroke. Zhang Xuewen[20] and Li Qiao[21] suggested that craniocerebral water stasis is the main mechanism of this disease, and believed that during the acute stage of stroke, stasis of blood stagnates internally, and water and fluid seeps externally, which can easily result in the water stasis syndrome of water and blood stagnation intertwined in the brain. Treatment should be combined with activating blood circulation and removing blood stasis and diuresis, which is believed that activating blood circulation can promote diuresis, and diuresis can promote activating blood circulation. This method has the effect of dilating blood vessels and relieving vascular spasm, etc. The oral solution of Cerebral Orgotonics, which is made by the method of activating blood and inducing diuresis, has achieved remarkable therapeutic effect in the treatment of this disease. 4.1.2 Resolving phlegm and clearing the channels:Some doctors believe that the symptoms of phlegm are especially prominent in the acute stage of ischemic stroke, so according to the condition of the phlegm method with blood circulation and clearing the channels or with other treatments for the treatment of this disease [22]. Sun Xiqing [23] used the method of phlegm elimination combined with blood activation and wind quenching to treat 32 cases of acute cerebral infarction, with a total effective rate of 95.5%, which was significantly better than that of the control group. Shujin [24] used the method of benefiting qi, activating blood and resolving phlegm to treat this disease, and the result was that among 61 cases, there were 32 cases with obvious effect and 26 cases with remission, and the total effective rate was 95.1%. 4.1.3 Method of activating blood and removing blood stasis:Bow Wenzhong[25] used the method of activating blood and removing blood stasis to treat ischemic stroke, with an overall effective rate of 100%. Chen Yuheng[26] used the method of activating blood and removing blood stasis to treat 68 cases of ischemic stroke with satisfactory results. Based on clinical treatment experience, Wang Jianxin [27] and others proposed that the essence of stroke disease is blood stasis, and the treatment is to eliminate blood stasis, and the method of activating blood circulation and removing blood stasis should be carried out throughout the treatment, and according to the different clinical patterns, appropriate with the corresponding methods, which can obtain complementary effects. 4.2 Dialectic typing treatment Wang Yongyan [28] and others classified 100 cases of acute ischemic stroke into wind-phlegm and blood stasis, paralysis obstruction, wind-phlegm upturn, phlegm-heat and viscera solidity, qi deficiency and blood stasis, and yin deficiency and wind movement based on the different clinical manifestations, and treated them with the Compound Blood Activating Injections composed of Danshen, Paeonia lactiflora, and Yujin. The efficacy rate reached 80%, which was a great improvement in efficacy compared with the results achieved by the method of dialectic treatment alone (efficacy rate of 62.5%). Yang Renmin [29] categorized acute cerebral infarction into 6 types: qi deficiency and blood stasis type, treated with tonifying yang and returning five soups with additions and subtractions; wind and phlegm upturned type, treated with big gentiana soup, pulling the Zhengsan with additions and subtractions; phlegm-heat and viscera solid type, mainly with niu huangwan and cheng qi soup; phlegm turbidity upturned type, treated with semixia and baijutsu and tianmazhou soups with additions and subtractions. Huang Peixin [30] and others divided into 9 types, including phlegm-heat viscera solid, wind-phlegm upward disturbance evidence, to wake up the brain Jing injection; wind-phlegm blood stasis, paralysis blockage of veins and collaterals evidence to Chuanxiongxin injection; phlegm-heat internal closure of the heart orifices evidence, phlegm-dampness blockage of the heart and God’s evidence, to the Thrombophorus injection, compound Danshen injection. 4.3 Specialized prescriptions and medicines Yang Xiaoheng et al [31] treated 156 cases of acute stage of cerebral infarction mainly by activating blood circulation and resolving phlegm, with the composition of prescriptions: chuanxiongxiong, danshen, safflower, hyssop, dilong, motherwort, peach kernel, zejiao, bile nansing, and tianzhu huang. Add according to the evidence, add tianma and hook vine for hyperactivity of liver yang; add scutellaria and gardenia for heat abundance. Water decoction, 1 dose per day, each decoction of 400 ml, divided into 2-3 times orally, for 1 month, and set up a western medicine control group, the results of the total effective rate of 88.5% in the treatment group, 76.2% in the control group, the comparison of the two groups has a highly significant difference (P < 0.05 =.). Xu's [32] treatment of acute stroke using Ke paralysis decoction formula, drug composition: leeches 3g (2 times research swallow), peach kernel, safflower, angelica, rhizoma ligustici chuanxiong, dan shen, dilong 10g each, red peony, motherwort 15g each, the raw land 20g day 1 dose of water decoction. Huang Wenzhu [33] used the treatment of acute cerebral infarction by cleansing phlegm and activating blood circulation soup with the following ingredients: 6g each of bilberry, tangerine red and Citrus aurantium, 10g each of Semen xia, chicken-blood vine and safflower, 15g each of Poria and Salvia divinorum, 30g each of Piper betle, 3g each of rhubarb with additions and subtractions to treat 42 cases, with an overall effective rate of 95.2%. Fu Renjie[34] treated 35 cases of acute cerebral embolism with Tongluo wind-extinguishing injection (made by extracting the active ingredients of astragalus, danshen, red peony and other medicines, produced by Beijing Yimin Pharmaceutical Factory, each 10ml contains 10g of raw medicines) 20ml of static treatment, and 51 cases of the control group were treated with 500ml of static drip of low molecular dextran in a total effective rate of 85.93% and 60.76%, and the comparison of efficacy of the two groups had a very significant difference (P