Getting up every morning in an irritable mood, while this mood improves in the evening or afternoon, is clinically called the phenomenon of day-heavy mood and night-light mood. Patients with depression are more likely to appear, especially in the morning when they get up, feeling that they do not know how to spend the whole day, low mood, depressed mood, unhappy, sad face, slow brain reaction, and patients have lower self-evaluation, lack of interest, fun, no energy in the process of doing things, lack of experience of pleasure, feeling that there is no meaning in living, and sometimes suicidal and self-injurious thoughts and behaviors. In this case, it is very important to carry out systematic antidepressant treatment, especially pharmacological treatment, applying 5-hydroxytryptamine reuptake inhibitors such as paroxetine and sertraline, which can achieve good results. Psychotherapy, which can help patients with cognitive reconstruction and improve their mood state, and physical therapy, which can also improve patients’ mood, such as transcranial magnetic stimulation, electroconvulsive therapy, etc.