A single hepatitis B core antibody of 2.54 in a pregnant woman cannot determine the normal condition of a pregnant woman, but only indicates that she has been infected with the hepatitis B virus. Core antibody is one of the five hepatitis B tests, which means that she has been infected with the hepatitis B virus, and it is of little clinical significance if it is used alone, but should be used together with surface antigen and e antigen to have clinical significance. If the surface antigen is positive, the e antigen or e antibody is positive, it means that the hepatitis B virus is present, which is not normal and should be treated actively, and the newborn will also get hepatitis B if mother-to-child interruption is not performed. If only the core antibody is 2.54 and the hepatitis B panel is negative, it is normal, which means that the patient has been infected with the hepatitis B virus in the past, but the virus has been completely cleared. It is recommended that the results of all five hepatitis B tests should be analyzed together and a professional doctor’s opinion should be consulted.