Hepatitis B five (also known as “two-and-a-half”) is a common clinical laboratory test, which is now available in almost all levels of hospitals as a routine medical checkup, and is generally included in various medical examinations. This can lead to two possibilities, either causing unnecessary panic to the patient, or making the patient who needs treatment blindly optimistic and neglecting the disease. The following, in my long-term clinical work in hepatitis B found some errors to do to analyze. 1, what is hepatitis B five? Hepatitis B five (also known as two and a half) includes surface antigen (HBSAg) and surface antibody (anti-HBs or HBsAb), e antigen (HBeAg) and e antibody (anti-HBe or HBeAb) and core antibody (anti-HBc or HBcAb). The significance of the hepatitis B two-to-one test, also known as the five hepatitis B tests, is to check whether you are infected with hepatitis B and the specifics of the infection, and to distinguish between major and minor triplets. Hepatitis B five and liver function are two different tests, they are completely different, many patients can not distinguish between them. However, in order to protect the privacy of hepatitis B patients, the state currently stipulates that only the liver function is checked in some medical examinations and not the hepatitis B five items. However, it must be reminded that normal liver function is not equal to the absence of hepatitis B. It is necessary to go through the five hepatitis B tests to determine whether you have hepatitis B. 2.What is AusA positive? The surface antigen (HBsAg) was first known as Australian antigen, or AoA for short. In the past, many medical checkups or primary hospitals only checked for hepatitis B surface antigen without performing the five tests, so we used to refer to hepatitis B virus-infected patients as AoA-positive patients. This name is no longer in use, but it is a convention that many people still use this name. Some people even say, “I’m only AUD positive, I don’t have hepatitis B”. This is extremely wrong, because an AoA-positive person is chronically infected with the hepatitis B virus. The five tests for hepatitis B are usually either a major or minor triple-positive. If you have a family member who is “Aussie positive”, then you must check carefully to see if you have been infected. 3, small three yang must be better than large three yang? The “major triple-positive” refers to the three positive cases of surface antigen (HBsAg), e antigen (HBeAg) and core antibody (anti-HBc or HBcAb). A “minor triple positive” is a condition in which the person is positive for surface antigen (HBsAg), e antibody (anti-HBe or HBeAb) and core antibody (anti-HBc or HBcAb). If the minor triplet is accompanied by a long-term negative HBV-DNA quantitative test, it means that the patient is in immune control, which is a relatively good state. However, if the small triplet but HBV-DNA quantitative test is positive, there is likely to be a pre-HBV C-zone variant, which is more troublesome to treat than the large triplet, and there may also be a greater risk of developing liver cancer. Therefore, small triplets may not be better than large triplets, but also depends on the quantitative HBV-DNA test results and other test results, small triplets do not miss the disease because of blind optimism. 4, “one, five-positive” is better than small three-positive? The “one, five-positive” refers to the surface antigen (HBsAg) and core antibody (anti-HBc or HBcAb) these two positive, some patients and even some doctors also think that the less positive results of the five hepatitis B the better, so it is taken for granted that “one, five-positive “The more positive the result, the better. “This kind of result is more often found in the test results of domestic reagents, if you use more sensitive imported reagents, this situation generally belongs to the “big three yang”, generally the e antigen ( The level of HBeAg is low, and if the reagents with poor sensitivity are used, the result will be “one or five positive”. If the patient was originally a major triple-positive, the appearance of “one or five positives” may be a prelude to the conversion of e antigen (HBeAg), which is generally a good sign. If the patient was originally a minor triple-positive, the appearance of “one or five positives” may be a sign of active viral replication again and aggravation of the disease. Therefore, if you change from small three yang to “one or five yang”, you should not be blindly optimistic. 5. What is “two or five-positive”? Many people are found to be “two or five-positive” during physical examinations, that is, positive for both surface antibodies (anti-HBs or HBsAb) and core antibodies (anti-HBc or HBcAb). These people are often very frightened due to their lack of medical knowledge. “Two or five-positive” generally means that they have been infected with the hepatitis B virus in the past, and now the virus has basically cleared and the body is recovering. However, there are some patients who still have abnormal liver function and positive HBV-DNA, so it is important to consider whether the virus has mutated and continue treatment. Therefore, the majority of people with “two or five positive” are healthy people who have developed immunity. If you are not sure, you can further check HBV-DNA quantification and other tests to clarify.