There is no easiest way to determine AIDS in men, it is mainly combined with medical history, clinical manifestations, and laboratory tests to confirm the diagnosis. 1. Medical history: for example, having unclean sex, intravenous drug use, blood transfusion and other high-risk contacts. 2. Clinical manifestations: fever, malaise, sore throat, rash, enlarged lymph nodes and other symptoms without any cause. 3. Laboratory tests: HIV antibody test, qualitative and quantitative HIV nucleic acid test. HIV-1/2 antibody test is the gold standard for diagnosis of HIV infection. If there is a history of risky contact and clinical symptoms, combined with laboratory tests, it is generally possible to diagnose whether or not the infection is AIDS, and the patient needs to go to a regular medical institution for examination and diagnosis and treatment.