If the gurgling in the stomach is due to physiological factors, there is no need to take Trimethoprim Maleate; if it is due to gastrointestinal dysfunction, you can take Trimethoprim Maleate. 1. Physiological factors: because of a long period of time without food, stomach emptiness caused by the stomach grumbling, do not need to take Trimethoprim Maleate, intake of food can gradually improve. 2. Gastrointestinal dysfunction: Gastrointestinal dysfunction leading to loss of appetite, nausea, vomiting, abdominal distension, gurgling in the stomach and other symptoms, you can take Trimethoprim maleate. Trimethoprim maleate may cause diarrhea, bowel sounds, constipation, thirst, headache, dizziness, hepatic impairment and other adverse reactions, and should be used with caution in pregnant and lactating women, and is recommended to be used under the guidance of a physician. Gurgling in the stomach exists a variety of causes, in addition to gastrointestinal dysfunction, does not exclude gastritis and other gastrointestinal diseases, it is recommended to consult a doctor in a timely manner, to clarify the cause of the disease, under the guidance of a physician to use medication, do not unauthorized use of medication, delayed condition.