Hepatitis B minor tri-positive patients may have different manifestations in different people. If a patient with hepatitis B minor tri-positive has negative hepatitis B virus DNA quantification and normal liver function, he may not have any clinical symptoms. If the patient is positive for hepatitis B virus DNA and has abnormal liver function, he will have some symptoms, such as abdominal distension, nausea, vomiting, aversion to greasy food, poor appetite, and even jaundice, so it is not that the condition of hepatitis B minor tri-positive is less severe than that of hepatitis B major tri-positive. The patients with small hepatitis B triplets should also do regular review, which can be done once every six months, mainly including liver function, hepatitis B virus DNA quantification, hepatitis B five quantification, fetal protein, liver ultrasound, liver elasticity and so on. Once the indications for antiviral treatment are reached, antiviral treatment must be carried out in time to avoid continued progression of the disease, which can otherwise progress to hepatitis, cirrhosis or even liver cancer.