Traumatic brain injury includes severe cranial injury, cerebral contusion, diffuse axonal injury, subdural hematoma and epidural hematoma, etc. Traumatic brain injury is a common cause of death and disability in people under the age of 50, and it is also the second leading cause of death in men under the age of 35. With the improvement of medical treatment, the mortality rate of traumatic brain injury has decreased significantly compared to the previous, but the disability rate remains high. Symptoms include motor, sensory, speech, visual and auditory disturbances, and impaired consciousness. Hyperbaric oxygen has been used to treat traumatic brain injury from various causes for more than 50 years, and foreign reports on hyperbaric oxygen therapy for neurosurgical diseases were published in 1967. Since the 1990s, there have been numerous clinical reports and studies every year. Early hyperbaric oxygen therapy can promote nerve repair and reduce cerebral edema, which can lead to recovery of consciousness and decrease of disability rate. In the past 20 years, our department has cured numerous patients and published papers on this topic in professional journals. The timing of starting hyperbaric oxygen therapy in patients with traumatic brain injury. Generally speaking, patients’ vital signs are unstable after craniotomy for traumatic brain injury, and postoperative patients have to go through pathological processes such as cerebral edema, cerebral hemorrhage, infection, and gastrointestinal bleeding. Hyperbaric oxygen therapy can be considered after the vital signs are stable and the condition is relatively stable. Whether a patient can be treated with hyperbaric oxygen therapy should be weighed by the hyperbaric specialist according to his or her condition. If the vital signs are stable and contraindications to hyperbaric oxygen are ruled out, hyperbaric oxygen therapy should be given as soon as possible, the earlier the treatment, the better the efficacy and the less the sequelae. Hyperbaric oxygen therapy for acute craniocerebral trauma and its brain dysfunction is eligible for reimbursement by Beijing medical insurance.