Viral sinusitis does not need infusion treatment, acute bacterial sinusitis can choose amoxicillin clavulanate potassium, cefuroxime sodium infusion treatment, can also choose mometasone furoate nasal spray, montelukast sodium and other auxiliary treatment. Not all sinusitis need infusion treatment, if for the common cold caused by viral sinusitis, generally do not need antibiotic treatment. When bacterial sinusitis is considered, amoxicillin clavulanate potassium and cefuroxime sodium are recommended by the CDC as anti-infectives for 7-14 days against the common causative bacteria of the upper respiratory tract. Combined with mometasone furoate nasal spray for anti-inflammation; oral medications, loratadine antihistamine or montelukast sodium anti-leukotriene to relieve nasal symptoms; and nasal rinses to reduce nasal secretions. Selected amoxicillin clavulanate potassium need to pay attention to, penicillin drug allergy is prohibited, hepatic and renal insufficiency should be used with caution, must be skin test before using the drug, the common adverse reactions for rash, nausea, vomiting, dizziness, headache and so on. Selection of cefuroxime sodium most common neutropenia, transient glutamic transaminase, glutamic alanine transaminase elevation. Allergy to cephalosporins is contraindicated. Suffering from sinusitis does not always need infusion treatment, suffering from sinusitis is recommended to the hospital, follow the doctor’s instructions for medication and treatment.