Pancreatic cancer patients receive surgical treatment, whether the total resection needs to be judged according to the situation, usually partial resection (such as pancreatic body tail splenectomy, etc.) Pancreatic cancer is a group of malignant tumors originating from pancreatic ductal epithelium or follicular cells, with a high degree of malignancy, no obvious accompanying symptoms in the early stage, rapid progression, and extremely poor prognosis. The best treatment for pancreatic cancer is radical resection, but considering that some patients’ early symptoms are not obvious, the vast majority of pancreatic cancer patients are in advanced or progressive stages of the disease at the time of diagnosis. Its treatment is mainly radical surgical resection: it is only limited to the tail and head of the pancreas, etc., and there is no obvious invasion of the surrounding tissues and distant metastasis, so it can be radical/expanded resection, etc., such as pancreatic tail cancer patients can receive pancreatic body-tail splenectomy. Total pancreatectomy is usually suitable for diffuse infiltration of cancer cells and is very rare, and stubborn hyperglycemia can be seen after surgery. Other treatment options also need to be chosen according to the patient’s specific situation, such as: 1. Chemotherapy: mainly used for adjuvant treatment after surgery or inoperable patients, such as gemcitabine combined with albumin combined with paclitaxel or gemcitabine combined with Tegretol. 2. Immunotherapy: immune checkpoint inhibitors are used to treat patients with metastatic pancreatic cancer characterized by high microsatellite instability or mismatch repair defects. 3. Targeted therapy: For patients with the presence of NTRK fusion gene, larotrectinib or entrectinib, etc. are preferred. If pancreatic cancer is suspected or diagnosed, it is recommended to go to a regular hospital for comprehensive assessment of the condition and follow the doctor’s instructions for treatment to avoid delay.