Dr. Gu has been engaged in the prevention and treatment of diabetes mellitus for more than 40 years. As early as in the 1970s, he proposed the idea of treating diabetes mellitus from the spleen. After years of practice, it is confirmed that the treatment of diabetes from the spleen and the treatment of nourishing Yin and invigorating Blood are unique and effective. The main points of his treatment of diabetes are introduced as follows: 1. As early as in the “Nei Jing” that is recorded, such as the “Spiritual pivot – this organ chapter” said: “spleen brittle …… good disease thirst”. And Su Wen – Dou Qi Fa Shi Lun also clouded: “Spleen disease, body heavy and good hunger”, it can be seen that spleen deficiency is the pathological basis for the development of this disease. The modern medical doctor Zhang Xichen also believes that “the evidence of thirst, all start in the middle jiao and up and down”, and clearly pointed out that: “because of the disease in the middle jiao, but also involved in the spleen. …… cause spleen qi can not disperse essence to reach the lungs, then fluid is less, can not regulate the water channel, then urination is uncontrolled, is thirsty and more drinking and more urination”. This shows that the thirst disease is the spleen disease and, spleen, the same disease caused. This is the secondary organ of the spleen, which is also known as the pancreas in modern medicine. My teacher believes that the pancreas in modern medicine can secrete pancreatic enzymes to digest sugary foods and secrete insulin to participate in the regulation of sugar metabolism to break down glycogen so that it can be used by tissues and play its physiological role. These physiological functions of the pancreas are very compatible with the physiological functions of the spleen in Chinese medicine, such as “main transport and transformation” and “overflowing essence”. Therefore, my master attaches great importance to the status and role of the spleen in the process of the onset, development and regression of diabetes. If the spleen is deficient in transporting and transferring the essence of water and grain, the essence of water and grain will slip down and become urine, resulting in heavy urine and a sweet taste; if the essence of water and grain cannot moisten the muscles, the body will gradually lose weight; if the spleen does not raise the essence of water, the essence of water will not be distributed, resulting in a dry mouth and a desire to drink; if the spleen is deficient in yin, it cannot move its fluids for the stomach, resulting in a burning fire in the stomach, resulting in thirst and excessive drinking, and the consumption of grain and hunger. Therefore, my master emphasizes that the diagnosis and treatment of this disease must focus on treating the spleen, and according to its clinical symptoms, the specific treatment methods are applied to strengthen the spleen and transport the middle, nourish and clear the spleen and stomach, tonify the qi and ascend the spleen, fang the spleen and awaken the spleen, and nourish the spleen and kidney, etc. The formula of Si Jun Zi Tang, Tonifying Zhong Yi Qi Tang, Ascending the spleen and Stomach Tang are added and subtracted, focusing on strengthening the spleen and nourishing the stomach. Ginseng, Astragalus, Atractylodes, Atractylodes, Poria, Chinese yam, Radix et Rhizoma, Radix et Rhizoma, Radix et Rhizoma, Radix et Rhizoma, and Radix et Rhizoma Chicken Neijin are commonly used in the formula. Case: Song, female, 49 years old, was found to have type 2 diabetes mellitus 2 years ago due to polyphagia, polyphagia and polyuria. At the time of consultation, she was thin, fatigued and weak, with numbness in both hands, blurred vision and a dry mouth. The tongue is light red with a slightly yellowish greasy moss. Pulse is weak. Fasting glucose 12.4 mmol/L and urine glucose (+++). The treatment is to benefit Qi and strengthen the spleen, slightly complemented by clearing the liver and brightening the eyes. Herbs: Astragalus membranaceus 30g, Radix Astragali 30g, Rhizoma Atractylodis Macrocephalae 1 5g, Atractylodes Macrocephalae 15g, Perillae 15g, Radix et Rhizoma Macrocephalae 30g, Radix Ginseng 12g, Radix Puerariae 15g, Salviae Miltiorrhizae 20g, Radix et Rhizoma Gynostemma 15g, Datura 20g, Radix et Rhizoma Dioscorea 20g, Radix et Rhizoma Dioscorea 15g, Chrysanthemum 15g, Radix et Rhizoma Guggul 15g. The above formula was used for more than 60 doses of herbal medicine, and the fasting blood sugar was repeatedly checked between 5.1 and 6.0 mmol/L, and the urine sugar (one). All the symptoms were also removed. 2, nourishing Yin and invigorating Blood, throughout the pathogenesis of diabetes mellitus, both based on Spleen deficiency, so the Spleen Qi is weak, and the deficiency of Yin and fluid. Therefore, in the process of treating diabetes, our master does not forget to protect the spleen and yin, and often uses such medicines as Wu Mei, Bai Shao, yam, lentil, Cornus officinalis, Pueraria lobata, Dendrobium, papaya, and rhizome to sour and sweeten the yin. The weakness of spleen qi, the dysfunction of the spleen and stomach, the lack of smooth flow of qi and blood, and the eventual stasis of the veins and channels, especially in the pancreatic gland and pancreatic islet beta cells, pancreatic ducts and other parts of the pathological changes of stasis are more obvious. Modern medicine also believes that the main link of type 2 diabetes is the acute and chronic inflammation of the pancreas caused by various factors that damage the pancreatic islet beta cells, resulting in insufficient insulin secretion. The pathology can be seen in the islets of the pancreas with proliferation of paracapillary fibrous tissue and even extensive fibrosis, which has also been confirmed in the autopsy of diabetic patients. This has also provided an important basis for our treatment of diabetes mellitus, which must be carried out with the formula of activating blood circulation and removing blood stasis. Therefore, in the treatment of diabetes mellitus, our master often selects Danshen, leeches, soapberry, piercing nail, Wang Bu Liuxing, peach kernel, safflower, motherwort, raw hawthorn, chicken’s nest, septoria, curcuma and other blood activating and stasis-removing products to be added to the basic formula to achieve the purpose of activating blood circulation and eliminating stasis. Case: Zhuang, male, 54 years old, suffered from acute jaundice 2 years ago, and recently came to the clinic with significant weight loss and dry mouth. Check: fasting blood glucose 10.93mmol/L, 2h postprandial blood glucose 1 6.19mmol/L, insulin and C-peptide release function is still acceptable. He felt dizzy, weak and easily tired, with blurred vision and slight numbness of hands and feet. The tongue is light purple with thin white coating. The pulse is weak. Diagnosed as type 2 diabetes mellitus, he was given to benefit Qi, nourish Spleen and Yin, and activate Blood circulation. Herbs: Astragalus membranaceus 20g, Radix Astragali 30g, Rhizoma Polygonati 30g, Ganoderma lucidum 15g, Radix Angelicae Sinensis 10g, Radix Paeoniae Alba (each) 15g, Semen Aconiti 15g, Radix Guggul 20g, Dendrobium dendrobium 15g, Papaya 20g, Radix Cicadelliae 10g, Crataegus spp. 20g, Lychee kernel 15g, Fructus Gargantua 15g, Rhizoma Tian Tian Tian 15g, Rhizoma Huang Lian 3g, Radix Salviae Miltiorrhizae 15g, Radix Erythrinae 20g, Peach kernel l0g. After 1 month, the fasting blood glucose was 6.1mmol/L and 2h postprandial blood glucose was 8.6mmol/L. Self-perceived symptoms also disappeared.