With the popularity of unit checkups and an aging population, men over the age of 55 are increasingly coming to urology clinics with “elevated PSA”. PSA elevation phobia” is increasingly prevalent among older men. Because PSA/fPSA is often classified as a “tumor marker” in medical tests, most patients tend to panic when they find elevated PSA. The actual PSA, the full Chinese name is “prostate-specific antigen”, as the name implies, is a protein component secreted by the prostate gland in men’s bodies, and never called “prostate cancer-specific antigen”. ”This is not the same as “prostate cancer specific antigen”. There are many conditions that can cause a transient increase in PSA, such as acute urinary retention, post-ejaculation, or inflammation of the prostate. In most cases, the PSA is <4 after the above conditions have been ruled out, but if the PSA is between 4 and 10, or if we simply do not know if other factors are at play, we still suspect the possibility of a tumor. Then further tests are needed. One of the most crucial is a prostate puncture biopsy. The actual prostate puncture biopsy preparation 1, clean bowel, reduce infection: in the day of puncture to be clean enema + antibiotics (metronidazole) retention enema, reduce the chance of infection. 2, diet: light diet, generally no special requirements. 3, improve the examination: blood routine, coagulation function is the necessary examination. 4, blood sugar, blood pressure control, to avoid puncture stimulation caused by serious cardiovascular and cerebrovascular complications. 5, prostate magnetic resonance. Precautions after prostate puncture biopsy 1.What are the adverse effects of puncture Fever, infection, urinary retention, hematuria, bloody stool. 2.What if the puncture result is cancer? According to pathological results, imaging data. If the body tolerates it, laparoscopic radical prostatectomy is recommended for early stage prostate cancer; endocrine therapy is recommended for advanced prostate cancer. 3.What if the puncture result is not cancer? If there is still a high suspicion of tumor, repeat the puncture within three months. If tumor is considered unlikely, PSA can be repeated after three months.