The urethra is a single layer of columnar epithelium, the local more moist, local immunity is reduced, if the treatment method is not appropriate, easy to lead to urethral warts difficult to cure easy to recur, in addition to easy to lead to urethral discomfort for a long time is not easy to subside, and even lead to urethral scarring. I have more than 20 years of experience in the treatment, summarized as follows: 1, can choose topical drugs such as Paitling solution, ghosts tincture of toxins, such drugs are more effective, but the medication is more troublesome, there is local irritation, if not good, easy to appear local erosion, the length of time with the medication varies, to be used under the guidance of experienced doctors, the cost is appropriate. 2, those who have the economic strength, can choose photodynamic therapy treatment, the method clearance rate is higher, the recurrence rate is lower, clear subclinical infection and latent infection lesions, generally do not leave scars, especially for the treatment of male urethral opening and other special anatomical parts, but the cost is higher, the operator’s experience is also more important. 3, try to avoid using laser, electrocautery, freezing and other treatments, one is more likely to recur, in addition to easily lead to urethral discomfort for a long time is not easy to subside, and even lead to urethral scar, I encountered more such cases in the clinic. 4, available interferon local injection or intramuscular injection, also available polymyocyte, thymidine, Wilburn and Skykom (BCG) and other intramuscular injection, to improve the body’s immune function. 5, eating habits, smoking, drinking, staying up late, mood, etc. also have an impact on the treatment, and should be controlled and adjusted. The choice of the above treatment methods is not absolute, but depends on the experience of the doctor, the treatment conditions in different places, and the economic conditions of the patient, but choosing an experienced doctor is the key.