Usually, amniocentesis does not detect Maffon syndrome. Mafontaine syndrome is a hereditary connective tissue disease, which belongs to autosomal dominant disease. Patients usually have cardiovascular system diseases such as progressive dilatation of aorta, aortic valve insufficiency, mitral valve prolapse, etc. In appearance, they will have long limbs and be taller than ordinary people. And amniocentesis is mainly through chromosome karyotype analysis to exclude some genetic diseases, such as can exclude trisomy 21, trisomy 18, etc. Usually, the test can not detect equine syndrome. Pregnant women should pay attention to rest more in daily life, avoid staying up late, keep a happy mood, do not have too much pressure, and go to the hospital regularly for review.