Amenorrhea occurs during perimenopause, mainly due to ovarian hypofunction, and the use of hormonal drugs can promote menstruation as quickly as possible. When a woman uses hormonal drugs, she should first have an ultrasound to observe the thickness of the endometrium and then check the sex hormone panel to observe the ovarian function of the patient before choosing the type and dosage of medication. If the patient’s endometrial thickness exceeds 0.8 cm and the patient’s ovarian function is not in serious decline, she can choose to use progesterone to promote menstruation by injecting progesterone for three consecutive days and stopping it for one week or taking progesterone orally twice/day for 5-7 days and stopping it for one week. If the patient has a thin endometrium and the ovarian function is in serious decline, it is necessary to use estrogen and progesterone combination such as Clomid or Fentanyl to promote menstruation.