Hepatitis B surface antigen greater than 25,000 ng/ml is not reasonable, hepatitis B surface antigen greater than 25,000 ng/ml usually indicates the presence of hepatitis B virus infection, but is not proportional to the severity of hepatitis B disease. Hepatitis B surface antigen refers to the hepatitis B surface antigen, which is not the complete hepatitis B virus itself, but the shell of the hepatitis B virus, and can be used as one of the signs of hepatitis B virus infection. The normal value of Hepatitis B surface antigen is below 0.5ng/ml. If the test result shows that Hepatitis B surface antigen is greater than 25,000ng/ml, it means that the body has been infected with Hepatitis B virus. However, only relying on the value of hepatitis B surface antigen is not able to determine whether the condition is serious or not, and it needs to be analyzed by the clinician in combination with the patient’s five indicators of hepatitis B, liver function, quantitative results of hepatitis B virus and other tests. If the test result shows that the surface antigen of hepatitis B is more than 25000ng/ml, the patient should consult a doctor in time for further examination and active treatment, and the severity of the disease will be reduced after controlling the condition.