A large gap between the upper incisors of infants may be a normal phenomenon, or it may be a pathologic factor, such as multiple teeth, low attachment of the labial tie, etc. Pathologic factors can be treated by tooth extraction, surgical treatment and so on. 1. Normal phenomenon: when infants are in the period of milk teeth, the permanent teeth have not yet fully erupted, the milk teeth will leave a certain space for the permanent teeth, therefore, infants will have a large gap between the upper incisors. This normal phenomenon does not require special treatment. Peculiar teeth: the plural teeth is in addition to the normal number of teeth in addition to the birth of more teeth, if the baby permanent teeth in the alveolar bone of the plural teeth, will lead to the upper incisor gap is large, this time need to be extracted for treatment. 3. Lip tie attachment is too low: if the baby’s lip tie attachment is too low, it will lead to a big gap between the upper incisors. At this time, under local anesthesia, the lip tie attachment can be cut, and after treatment, the upper incisors will gradually close to the middle and fill the gap. It is recommended that babies with large gaps in their upper incisors go to the hospital in time to find out the cause and follow the doctor’s instructions for treatment if necessary.