Many people have a vague understanding of the clinical significance of hepatitis B marker test results, especially the importance of the presence or absence of infectiousness, which is described here. It should be noted that hepatitis B is transmitted mainly through blood transmission, vertical transmission and sexual contact transmission. It can also be transmitted through contact with body fluids such as saliva, urine, lotion, semen, etc. of hepatitis B patients. However, the chances of this are small, only when the skin mucous membrane is broken contact with the above contaminated body fluids may spread, daily life such as, shaking hands, hugging, eating will not spread, should be treated correctly hepatitis B patients infectious problem. 1, hepatitis B “two pairs of half” (HBV five indicators) check when the situation of the major triple-positive, that is, surface antigen (HBsAG) E antigen (HBeAG) core antibody (HBcAG) positive at the same time, which is the classic combination of HBV pattern. Among them, E antigen positive is direct evidence of HBV replication, this situation occurs, indicating that there is HBV replication in the body, highly infectious. 2, hepatitis B “two pairs of half” test, there is a small triple-positive situation that surface antigen, E antibody, core antibody positive at the same time. At the same time, hepatitis B virus deoxyribonucleic acid (HBV-DNA) is positive, indicating that HBV has mutations occur, although the E antigen is negative, but and HBV-DNA is positive, enough to indicate that HBVAB in a replication state infectious strong. 3, hepatitis B “two pairs of half” test, surface antigen, core antibody is positive, even when only the core antibody is positive, HBV-DNA test is still positive, which still reflects the HBV is still in the replication state, infectious. 4, hepatitis B “two to half” test, only the core antibody is positive, but the core antibody immunoglobulin white M (anti-HBCIGM) is positive, also indicates that there is infectious. 5, hepatitis B “two and a half” test, all negative, but abnormal liver function, further examination of HBV-DNA or anti-HBCIGM is positive, can also indicate that HBV is still infectious. 6, if the blood HBV test is not found to be positive, but and liver function continues to be abnormal, by liver tissue biopsy, HBV E antigen or core antibody is found to be positive, it can still indicate that hepatitis B is infectious, the most important indicator to measure whether hepatitis B is infectious is HBR-DNA and E antigen, no matter what the case, as long as these two are positive, it can be considered that is infectious.