In simple terms, bile duct blockage is a condition in which bile produced by the liver does not enter the digestive system smoothly, resulting in a series of clinical symptoms, such as jaundice, clay-colored stools, diarrhea, right upper abdominal pain, itchy skin, nausea and vomiting, fatigue, weight loss, and fever. When bile ducts are blocked, bilirubin cannot enter the bile and collects in the body and causes jaundice, which results in yellow sclera and skin staining, and pale or clay-colored stools because bile cannot enter the intestines. Bile stagnates in the liver after the bile duct is blocked, causing the liver to increase in size and harden, thus causing a vague pain in the right upper abdomen. Due to the lack of bile acids and cholesterol in the bile ducts and the deficiency of fat-soluble vitamins, the symptoms of diarrhea, which is steatorrhea, are manifested. Bile salts are retained in the blood and irritate the skin nerve endings, thus causing symptoms of generalized itching. Because the bile ducts are blocked from delivering the needed digestive juices, they prevent the body from absorbing fats and vitamins, thus causing a series of symptoms such as weight loss, fatigue, nausea and vomiting. Also, bile stagnation can irritate the surrounding organs, causing inflammation and fever. When the above symptoms appear, you need to go to the hospital to improve the relevant aspects of the examination, confirm the diagnosis and timely treatment.