Albumin 28g/L belongs to hypoalbuminemia, which can be seen in patients with liver disease, malnutrition, massive loss of albumin, anemia, and renal insufficiency, so whether it is serious or not depends on the primary disease and whether it is combined with other index abnormalities. If it is caused by malnutrition, especially low protein intake, and there is no chronic underlying disease, supplementation, improvement of nutritional status and weight gain, this condition is not serious. For patients with chronic liver disease and cirrhosis, the presence of hypoproteinemia, suggesting a decrease in the liver’s albumin synthesis capacity, or caused by malnutrition but combined with hepatic ascites, jaundice, coagulation dysfunction, liver failure and other manifestations, is usually more serious. Chronic kidney disease causes excessive urinary protein, resulting in protein loss and causing hypoproteinemia, which can lead to nephrogenic ascites and nephropathy-related swelling. This condition should be treated in nephrology rather than relying solely on supplementation and protein.