Discontinuation criteria for hepatitis B major triple-positive: First, if nucleoside analogs are used for antiviral treatment, the course of antiviral treatment should not be less than 4 years. Second, the major triple-positive needs to be converted into minor triple-positive, and on the basis of the minor triple-positive, consolidate the treatment for more than 2 years. Third, if these conditions are met at the same time, discontinuation of medication should still be done with caution, because even if these conditions are met, discontinuation of medication is still very likely to relapse. In fact, HBV-RNA testing can be performed before stopping the drug. If the quantification of HBV-RNA testing is very low, it is safe to stop the drug and generally not easy to relapse. If the quantification of HBV-RNA test is very high, the drug cannot be discontinued.