Not all patients with hepatitis B virus need clinical treatment. For patients with hepatitis B virus who are only carriers, the hepatitis B virus DNA quantification and liver function are normal, and there are no obvious clinical symptoms and histomorphological changes in the liver, so they can be closely followed up regularly, but in daily life, attention should be paid to avoid drinking alcohol, eating fatty foods, staying up late and overworking. For patients with active hepatitis III, timely treatment is needed, as the quantification of viral DNA and transaminases will be significantly increased, so timely antiviral and hepatoprotective drugs should be administered. The former commonly used drugs include entecavir and adefovir, while the latter commonly used drugs include compound glycopyrrolate and reduced glutathione. If treated properly and at the right time, it is even possible for patients with hepatitis B major triple-positive to turn negative. However, since hepatitis B is prone to recurrent attacks, even if treatment results in better remission, close follow-up and observation should be observed. If major triple yang causes cirrhosis, portal hypertension, primary liver cancer or liver failure, complications also need to be addressed, and surgical treatment, such as liver cancer removal or liver transplantation, may even be required.