Whether thyroid cancer in the isthmus of the thyroid gland needs total resection is based on the size of the tumor, whether there is extra-thyroidal invasion, and the pathological type of the mass. 1. Total or near-total resection: patients with history of radiation to the neck, distant metastasis, cancer nodule invasion to both sides of glandular tissues, extrathyroidal invasion, the diameter of the mass is larger than 4cm, there are poor pathological types such as high cell type, columnar cell type, and multiple metastases to bilateral neck lymph nodes, and if one of the above is present, it is recommended that total or near-total resection should be carried out. 2. Lobectomy can only be considered if the mass meets all of the following requirements: no history of neck radiation, mass diameter <1cm, no distant metastasis, no extrathyroidal invasion, and no adverse pathologic type. After diagnosis of thyroid isthmus cancer, patients should go to the thyroid surgery department in time, and the choice of surgery type should be evaluated by specialized doctors. Patients do not need to be overly panic and anxious, and strictly abstain from smoking and alcohol.