There are several possible causes for the pain in the bones under the big toe: first, bone tumors, when there are tumors in the bones, there can also be pain in the bones of the big toe, then the relevant bone x-ray, CT and MRI should be performed for early diagnosis and treatment; second, tuberculosis, when there is bone tuberculosis, there can also be pain in the bones under the big toe, often accompanied by local redness and swelling and increased skin temperature. Third, infection, when the bones of the big toe are infected, there will be pain in the bones, which can be accompanied by inflammatory symptoms such as redness, swelling, heat and pain in the skin, and relevant blood tests and X-rays and CT examinations of the feet should be performed for diagnosis and treatment.